4C: Engineering Biomaterials for Cardiac and Pulmonary Uses
Time: 1:30 PM to 3:30 PM
Description
Advances in biomaterial design and microfabrication are enabling the creation of sophisticated in vitro models that recapitulate the cardiac and pulmonary microenvironments, offering new pathways for therapeutic development and disease understanding. These engineered platforms are being applied to develop treatments for acute conditions like viral infections, investigate chronic diseases such as fibrosis, and conduct testing to potentially reduce reliance on animal models. This session will further explore cutting-edge applications of biomaterials as both research tools and advanced therapeutics in cardiac and pulmonary medicine.
Moderators:
Claudia Loebel, M.D.
University of Pennsylvania
Yi Hong. Ph.D
Associate Professor of Bioengineering at UT Arlington
The University of Texas at Arlington
1:30 PM. 172. Engineering Controlled-Size Lung Organoids for Physiological in vitro Modeling of the Alveolar Epithelium.Kerry Rogy1, Ha Ram Nah1, David Habiel2, Salman Khetani1 1University of Illinois Chicago, 2Sanofi
1:45 PM. 173. Cardiac bilayer tissues modeling cardiomyocyte-mediated fibrotic switch of myofibroblasts.Emmanouil Agrafiotis, PhD1, Samuel J. DePalma, PhD2, Gonzalo Anyosa1, Katie Kim3, Darcy D. Huang4, Anya G. Coffeen Vandeven5, Austin E. Stis6, Jingyi Xia1, Brendon M. Baker, PhD3 1UNIVERSITY OF MICHIGAN, 2Broad Institute, 3UNIVERSITY OF MICHIGAN- ANN ARBOR, 4University of Pennsylvani, 5HSS/Weill Cornell, 6University of Florida
2:00 PM. 174. A Micro-Engineered Heart Tissue Model of Desmin-related Cardiomyopathy Caused by Mutant B Crystallin.Yasaman Kargar Gaz Kooh1, Bahareh Bahman1, Chen Zhao2, Ganesh Malayath1, Leah Hayem1, Ghiska Ramahdita1, Huanzhu Jiang1, Javier Santiago Perez3, Hsin Yi Chou1, Yuxuan Huang1, Xiucui Ma3, Guy Genin1, David Rawnsley3, Abhinav Diwan3, Nathaniel Huebsch1 1Washington University in St. Louis, 2Washington Unicersity in St. Louis School of Medicine, 3Washington University in St. Louis School of Medicine
2:15 PM. 175. A Compartmentalized Microphysiological System Modeling Bidirectional Crosstalk Between Activated Myofibroblasts and Proximal Microvasculature.Kairav Maniar, B.S.1, Jingyi Xia1, Brendon M. Baker, PhD2 1University of Michigan, 2UNIVERSITY OF MICHIGAN- ANN ARBOR
2:30 PM. 176. Suspension-based Cardiac Differentiation of HiPSCs Using Scaffold-Free Aggregates and Poly(Ethylene Glycol) Fibrinogen Microspheres Impacts Cell Populations, Cardiomyocyte Yield and Tissue Function.B Justin Harvell1, Shireen Singh1, Carissa A Lee2, Nikolas D Ferreira2, Francisco X Galdos2, Mohammadjafar Hashemi1, Sidra Y Xu2, Shenbageshwaran Rajendiran1, Selen Cremaschi, PhD1, Sean M Wu, MD, PhD2, Elizabeth Lipke, PhD1 1Auburn University, 2Stanford University
2:45 PM. 177. Improving Satellite Cell Delivery for Treating Peripheral Artery Disease via Platelet-Like Particle-Laden Fibrin Gels.Jared Albert1, Isabel Wallgren2, Lana Maizel1, Laura Hansen2, Ashley Brown, PhD1 1North Carolina State University, 2Emory University
3:00 PM. 178. Stiffness and Integrin Binding Influence Alveolar Epithelial Cell Plasticity.Mikala Mueller, MS1, Rachel Blomberg, PhD1, Anton Kary, BS1, Bradford Smith, PhD1, Amy Ryan, PhD2, Chelsea Magin, BS, PhD1 1University of Colorado Denver | Anschutz, 2Carver College of Medicine, University of Iowa
3:15 PM. 179. Developing an Electrically Conductive Cardiac Patch Encapsulating Genetically Modified Cardiomyocytes.Yamini Singh, M.Sc.1, Alejandra Patino-Guerrero, Ph.D.2, Kalpana Ravi, B.Tech.1, Wuqiang Zhu, MD, PhD2, Mehdi Nikkhah, Ph.D.1 1Arizona State University, 2Mayo Clinic