4E: Hemocompatability and Blood Symposium 1

Date: Thursday, March 26, 2026
Time: 1:30 PM to 3:30 PM

Room: Hanover CDE

Description

Biomaterial surfaces commonly initiate blood coagulation, posing a major barrier to the safe and effective use of blood-contacting devices such as stents, vascular grafts, catheters, and mechanical heart valves. In recent years, there has been a declining emphasis on investigating material-induced thrombosis and the development of novel materials and strategies to mitigate these challenges. This symposium will explore emerging strategies to enhance hemocompatibility, including surface passivation, bioactive coatings, and controlled release of anticoagulant agents. Topics will include mechanisms of blood-material interactions, thrombosis modeling, and translational approaches to improving vascular device performance.

Moderators:

Liszet Yeltsin Madruga
George Mason University

Elizabeth Brisbois, Ph.D
School of Chemical, Materials & Biomedical Engineering | Associate Professor | Distinguished Faculty Fellow
University of Georgia

Chris Siedlicki, MS, PhD
Jane A. Fetter Professor | Surgery
Penn State College of Medicine

Hitesh Handa, Ph.D
Professor and Regents' Entrepreneur
University of Georgia

1:30 PM. 188. Overview of New FDA Regulatory Science Tools (RSTs) for In Vitro Thrombogenicity Testing of Blood-contacting Medical Devices and Biomaterials. Qujin Lu, FDA.
2:00 PM. 189. Shear-Mediated Platelet Adhesion, Aggregation, and Embolization on Polyurethane.Ian Goetz1, Christopher Siedlecki2, Keefe Manning, PhD1 1The Pennsylvania State University, 2Penn State College of Medicine
2:00 PM. 193. Epoxy-Derived Covalently Crosslinked Slippery Organogel Coating for Improved Hemocompatibility with In Vivo Rabbit Model.Myddelton Parker1, Arpita Shome, Ph.D.1, Isabel Martinez1, Sumit Kumar, Ph.D.1, Tia Shorter1, Mark Garren, Ph.D.1, Meghan Lanchaster, DVM1, Ji Eun Park1, Chad Schmiedt1, Benjamin Brainard, VMD1, Elizabeth Brisbois, Ph.D.1, Hitesh Handa, Ph.D.1 1University of Georgia
2:15 PM. 190. Robust Catalytic Nitric Oxide Generation from Metal-Phenolic Networks for Vascular Access Technologies.Mark Garren, Ph.D.1, Ekrem Ozkan, PhD1, Morgan Ashcraft, PhD1, Lori Estes-Bright, PhD1, Divine Francis, PhD1, Rashmi Pandey, PhD1, Natalie Crutchfield1, Anil Kumar, PhD2, Elizabeth Brisbois, Ph.D.1, Hitesh Handa, Ph.D.1 1University of Georgia, 2College of Engineering
2:30 PM. 191. Thermoresponsive Chitosan-Based Hydrogel Coatings for Blood-Contacting Medical Devices.Ik Sung Cho1, Yasumichi Tsuboi1, Masaru Tanaka1 1Kyushu University
2:45 PM. 192. Thrombogenicity of Transcatheter Aortic Valves and the Valve Biomaterial Components.Madelynn Tung1, Monica Hinds, PhD1, Deirdre Anderson, PhD1 1Oregon Health & Science University
3:15 PM. 194. Minimizing Surface Interaction to Achieve Improved Hemocompatibility in Biomedical Surfaces.Christopher Siedlecki1, Gaurav Pandey2, Li-Chong Xu1 1Penn State College of Medicine, 2Pennsylvania State University

Description

1:30 PM. 188. Overview of New FDA Regulatory Science Tools (RSTs) for In Vitro Thrombogenicity Testing of Blood-contacting Medical Devices and Biomaterials. Qujin Lu, FDA.

2:00 PM. 189. Shear-Mediated Platelet Adhesion, Aggregation, and Embolization on Polyurethane.Ian Goetz1, Christopher Siedlecki2, Keefe Manning, PhD1 1The Pennsylvania State University, 2Penn State College of Medicine

2:30 PM. 191. Thermoresponsive Chitosan-Based Hydrogel Coatings for Blood-Contacting Medical Devices.Ik Sung Cho1, Yasumichi Tsuboi1, Masaru Tanaka1 1Kyushu University

2:45 PM. 192. Thrombogenicity of Transcatheter Aortic Valves and the Valve Biomaterial Components.Madelynn Tung1, Monica Hinds, PhD1, Deirdre Anderson, PhD1 1Oregon Health & Science University

3:15 PM. 194. Minimizing Surface Interaction to Achieve Improved Hemocompatibility in Biomedical Surfaces.Christopher Siedlecki1, Gaurav Pandey2, Li-Chong Xu1 1Penn State College of Medicine, 2Pennsylvania State University