5G: Extracellular Vesicles for Biomedical Applications
Time: 8:00 AM to 10:00 AM
Description
Extracellular vesicles (EVs) are natural nanoparticles that carry RNA, DNA, proteins, and lipids, and have been given much attention in recent years due to the growing knowledge of their role in driving disease and maintaining health. The objective of this session is to bring together investigators focusing on the characterization and biology of EVs, engineering of EVs, and their utility as diagnostic biomarkers and therapeutics. Example topics include EV nanomaterials science, the interaction of EVs with biological systems, EV biodistribution in vivo and pharmacology, and the utility of EVs for molecular targeting, imaging, diagnostics, immunoengineering, tissue engineering, and drug delivery. EVs from different sources including both mammalian and bacteria-derived EVs will be included.
8:45 AM. 266. Enhancing Anti-Tumor Effects of Engineered Extracellular Vesicles via Endocytosis Route Switching and Interferon Response Suppression.Zixuan Huang1 1Shanghai Jiao Tong University
9:00 AM. 267. Extracellular vesicle-crosslinked hydrogels with intrinsic angiogenic and immunomodulatory activity for regenerative tissue repair.Artemis Margaronis1, Santiago Correa1 1Columbia University
9:45 AM. 270. AI-Guided Peptide Ligand Discovery for Cell-Specific Gene Delivery to Human Inner Ear Organoids.Sophia Wang1, Xiaoshu Pan, PhD2, Zachary Greenberg, MS2 1Fulton Science Academy Private School, 2University of Florida
Local Delivery of miRNA Using an Injectable Click Hydrogel and Lipid Nanoparticle System.Thomas Jacobs, BA, BS1, Ila Hales2, David Cohen, MD1, Zvi Schwartz, PhD, DMD1, Barbara Boyan, PhD1 1Virginia Commonwealth University, 2Arizona State University