5G: Extracellular Vesicles for Biomedical Applications

Date: Friday, March 27, 2026
Time: 8:00 AM to 10:00 AM

Room: GH East AB

Description

Extracellular vesicles (EVs) are natural nanoparticles that carry RNA, DNA, proteins, and lipids, and have been given much attention in recent years due to the growing knowledge of their role in driving disease and maintaining health. The objective of this session is to bring together investigators focusing on the characterization and biology of EVs, engineering of EVs, and their utility as diagnostic biomarkers and therapeutics. Example topics include EV nanomaterials science, the interaction of EVs with biological systems, EV biodistribution in vivo and pharmacology, and the utility of EVs for molecular targeting, imaging, diagnostics, immunoengineering, tissue engineering, and drug delivery. EVs from different sources including both mammalian and bacteria-derived EVs will be included.

8:00 AM. 263. Local Delivery of miRNA Using an Injectable Click Hydrogel and Lipid Nanoparticle System.Thomas Jacobs, BA, BS1, Ila Hales2, David Cohen, MD1, Zvi Schwartz, PhD, DMD1, Barbara Boyan, PhD1 1Virginia Commonwealth University, 2Arizona State University
8:15 AM. 264. Extracellular Vesicle-Mediated Therapeutic Targeting for Modulating Enteric Neuroimmune Responses.Karla Ortega Sandoval1, Shreya Artha Raghavan, Associate Professor2, Natalia Higuita-Castro, Associate Professor3, Maria Rincon Benavides, Post Doctoral Scholar3, Daniel Velasquez Ramirez3 1Texas A&M, 2texas a&m university, 3The Ohio State University
8:30 AM. 265. Tissue-specific matrix-bound nanovesicles regulate the immunoregulatory process of biological mesh-aided abdominal hernia repair.zhengni Liu, /1, Beili Zhang, /2, Lei Liu, /3 1The University of Queensland, 2Shanghai JiaoTong University, 3Shanghai East hospital
8:45 AM. 266. Enhancing Anti-Tumor Effects of Engineered Extracellular Vesicles via Endocytosis Route Switching and Interferon Response Suppression.Zixuan Huang1 1Shanghai Jiao Tong University
9:00 AM. 267. Extracellular vesicle-crosslinked hydrogels with intrinsic angiogenic and immunomodulatory activity for regenerative tissue repair.Artemis Margaronis1, Santiago Correa1 1Columbia University
9:15 AM. 268. Impact of Estradiol-Priming on Elastic Matrix Regenerative Properties of Stem Cell Extracellular Vesicles and their Biodistribution in a Rat Abdominal Aortic Aneurysm Model.Ali Abba Mutah, MS1, Anand Ramamurthi, PhD, FAHA1 1LEHIGH UNIVERSITY, BETHLEHEM PA.
9:30 AM. 269. Urinary Extracellular Vesicles as Therapeutics for Autosomal Recessive Polycystic Kidney Disease (ARPKD).Yi Huang, Ph.D.1, Huihua Xing, Ph.D.1, Ali Osouli, M.S.1, Lisa Guay-Woodford, M.D.2, Eunji Chung, Ph.D.1 1University of Southern California, 2Children’s Hospital of Philadelphia
9:45 AM. 270. AI-Guided Peptide Ligand Discovery for Cell-Specific Gene Delivery to Human Inner Ear Organoids.Sophia Wang1, Xiaoshu Pan, PhD2, Zachary Greenberg, MS2 1Fulton Science Academy Private School, 2University of Florida

Description

8:00 AM. 263. Local Delivery of miRNA Using an Injectable Click Hydrogel and Lipid Nanoparticle System.Thomas Jacobs, BA, BS1, Ila Hales2, David Cohen, MD1, Zvi Schwartz, PhD, DMD1, Barbara Boyan, PhD1 1Virginia Commonwealth University, 2Arizona State University

8:30 AM. 265. Tissue-specific matrix-bound nanovesicles regulate the immunoregulatory process of biological mesh-aided abdominal hernia repair.zhengni Liu, /1, Beili Zhang, /2, Lei Liu, /3 1The University of Queensland, 2Shanghai JiaoTong University, 3Shanghai East hospital

8:45 AM. 266. Enhancing Anti-Tumor Effects of Engineered Extracellular Vesicles via Endocytosis Route Switching and Interferon Response Suppression.Zixuan Huang1 1Shanghai Jiao Tong University

9:00 AM. 267. Extracellular vesicle-crosslinked hydrogels with intrinsic angiogenic and immunomodulatory activity for regenerative tissue repair.Artemis Margaronis1, Santiago Correa1 1Columbia University

9:15 AM. 268. Impact of Estradiol-Priming on Elastic Matrix Regenerative Properties of Stem Cell Extracellular Vesicles and their Biodistribution in a Rat Abdominal Aortic Aneurysm Model.Ali Abba Mutah, MS1, Anand Ramamurthi, PhD, FAHA1 1LEHIGH UNIVERSITY, BETHLEHEM PA.

9:30 AM. 269. Urinary Extracellular Vesicles as Therapeutics for Autosomal Recessive Polycystic Kidney Disease (ARPKD).Yi Huang, Ph.D.1, Huihua Xing, Ph.D.1, Ali Osouli, M.S.1, Lisa Guay-Woodford, M.D.2, Eunji Chung, Ph.D.1 1University of Southern California, 2Children’s Hospital of Philadelphia

9:45 AM. 270. AI-Guided Peptide Ligand Discovery for Cell-Specific Gene Delivery to Human Inner Ear Organoids.Sophia Wang1, Xiaoshu Pan, PhD2, Zachary Greenberg, MS2 1Fulton Science Academy Private School, 2University of Florida