6B: Drug Delivery SIG 3: Next-Gen Nucleic Acid Delivery, Targeting, and Enabling Platforms

Date: Friday, March 27, 2026
Time: 1:30 PM to 3:30 PM
Room: Centennial I

Description

This session will survey the diverse range of contemporary drug delivery systems and innovations. Drug delivering biomaterials can include nanoparticles, hydrogels, nanofibers, cell and virus-derived particles, or bioconjugates. Payloads can include DNA, RNA, antibodies, recombinant proteins, or small molecules. Disease applications can range from neurodegeneration to autoimmune disease, trauma, infection, or cancer. Work at all scales, from basic formulation science through therapeutic application in disease models is welcome. Studies that critically evaluate the impact of injection route on treatment efficacy and/or use novel imaging modalities to evaluate drug delivery performance are especially encouraged.

Moderators:

Dhanashree Hemant Surve
University of Miami

Laura Bracaglia, Ph.D
Assistant Professor
Villanova University

John Clegg
Assistant Professor
Gallogly College of Engineering
Peggy and Charles Stephenson School of Biomedical Engineering
The University of Oklahoma

  • 1:45 PM. 286. Engineering placenta-tropic lipid nanoparticles to treat pregnancy disorders.Kelsey Swingle, Ph.D.1 1Rice University

  • 2:00 PM. 287. Airway delivery of circRNA using pulmonary-surfactant-coated lipid nanoparticles for cystic fibrosis gene therapy.Guizhi Zhu, PhD1 1University of Michigan

  • 2:15 PM. 288. Analysis of Light-Induced Degradation of Curcumin in UV-Crosslinkable PVA Microneedle Systems.Yeong Min Kang1, Min Hee Kim2, Won Ho Park1 1Chungnam National University, 2Kyungpook National University

  • 3:00 PM. 291. Modernizing Biolistic Delivery for High-Efficiency Delivery of DNA, Proteins, and CRISPR/Cas Editing Tools.Shan Jiang1 1Iowa State Unviersity

  • 3:15 PM. 292. Optimizing Polymer Nanoparticle-Mediated Nucleic Acid Delivery and Endosomal Escape for Inhibition of Endothelial Inflammation.Valerie Lallo, MS1, Laura Bracaglia, PhD1 1Villanova University

  • Ultrasound-responsive dendrimers for targeted cancer gene therapy.Nikita Sehgal, MS1, Kevin Schilling, PhD1, Carolyn Schutt Ibsen, PhD2, Jason Ware, PhD1, Sean Hamilton, PhD1 1Oregon Health& Science University, 2Oregon Health and Science University