7D: Granular & Macroporous Biomaterials for Tissue Engineering 2
Time: 8:00 AM to 10:00 AM
Description
Granular hydrogel materials emerged as a class of biomaterial that provide for well-defined in vitro and in vivo systems with plug-and-play components and tissue-mimicking 3D environments. Granular hydrogels are composed of a slurry of microgel particles that are assembled to form a larger porous structure. Microporous annealed particle (MAP) scaffolds are a subclass of granular hydrogel material with a void space network stabilized by inter-particle chemical bonds. The modular nature of granular hydrogels offers enormous tunability in not only the individual microgel design but also the homogenous or heterogenous microgel assembly into the bulk scaffold. This session will explore current advances in granular hydrogel technology, including MAP scaffolds, for both immune modulation, tissue repair, organ-on-a-chip, and 3D-printing applications.
Moderators:
Tatiana Segura
Duke University
Donald Griffin
The University of Virginia
8:00 AM. 364. Hyaluronic Acid Granular Hydrogels through Initiator-free Visible Light Mediated Crosslinking.Aina Solsona Pujol1, Keisuke Nakamura2, Jason Burdick, Ph.D.1 1University of Colorado Boulder, 2Kyoto University
8:15 AM. 365. Granular Hydrogel-Based Perivascular Niche Models to Examine Glioblastoma Invasion.Joel Kattoor1, Brittany Payan, B.S.2, Tejasvi Anand, B.S.1, Brendan Harley3 1University of Illinois Urbana-Champaign, 2University of Illinois Urbana Champaign, 3University of Illinois at Urbana Champaign
8:30 AM. 366. Dynamic granular hydrogels as a confinement model to assess pancreatic cancer cell fate.Ellen Frahm1, Chien-Chi Lin, PhD1 1Purdue University
8:45 AM. 367. Controlled Growth Factor Release from Granular Hydrogels for Lymphatic Vessel Formation.Salmady Ramos Valentin1, Daniel Montes Pinzon1, Rananjaya Gamage, PhD1, Donny Hanjaya-Putra1 1University of Notre Dame
9:00 AM. 368. Rheological Exploration of the Role of Microgel Polymer Network Structure and Interparticle Interactions on the Brittility of Granular PEG Hydrogel Biomaterials.Victor Rivera-Llabres, PhD1, Jiye Lee1, John Brownridge1, Simon Rogers, PhD1, Brendan Harley2 1University of Illinois Ubana-Champaign, 2University of Illinois at Urbana Champaign
9:15 AM. 369. Compressive Loading of Alginate Microgel-Spheroid Composite Scaffolds Induces Hypertrophic Chondrocyte Phenotype in Stem Cell Spheroids.David Ramos-Rodriguez1, Andrea Filler1, Sheetal Palle2, Shierly Fok1, Erika Wheeler1, Mason Caserta1, Connor Dorais1, J. Kent Leach1 1UC Davis Health, 2UC Davis
9:30 AM. 370. Filling The Void: Vasculogenic Assembly in Semi-Synthetic Granular Hydrogel Grafts.Michael Hu1, Despina Pavlidis1, Gonzalo Anyosa1, Ariella Shikanov, PhD1, Brendon M. Baker, PhD2 1University of Michigan, 2UNIVERSITY OF MICHIGAN- ANN ARBOR
9:45 AM. 371. Granular Biomaterial Platform Enables Vascularized Subcutaneous Cell Delivery.Jean-Pierre Pierantoni1, John-Paul A. Pham1, Nicole Racca1, Maria Coronel, PhD1 1University of Michigan