11:00 AM. 431. Synthetic Niches Enable Immunological Profiling and Early Prediction of Type 1 Diabetes Progression.Jyotirmoy Roy1, Yifei Jiang1, Amod Talekar1, Peter Sajjakulnukit1, Jessica King1, Lillian Holman1, Shahzad Sohail1, Brianna Ha1, Costas Lyssiotis1, Lonnie Shea1 1University of Michigan