2:00 PM. 174. A Micro-Engineered Heart Tissue Model of Desmin-related Cardiomyopathy Caused by Mutant B Crystallin.Yasaman Kargar Gaz Kooh1, Bahareh Bahman1, Chen Zhao2, Ganesh Malayath1, Leah Hayem1, Ghiska Ramahdita1, Huanzhu Jiang1, Javier Santiago Perez3, Hsin Yi Chou1, Yuxuan Huang1, Xiucui Ma3, Guy Genin1, David Rawnsley3, Abhinav Diwan3, Nathaniel Huebsch1 1Washington University in St. Louis, 2Washington Unicersity in St. Louis School of Medicine, 3Washington University in St. Louis School of Medicine